| ncRNA name | PVT1 |
| ncRNA Category | lncRNA |
| ID | 5820 |
| Ensembl | ENSG00000249859 |
| Synonyms | LINC00079, MIR1204HG, NCRNA00079, onco-lncRNA-100 |
| Disease name | retinoblastoma (RB) |
| Species | Homo sapiens |
| Tissues/Cell_line | RB samples, normal retinas; RB cell lines SO-RB50, WERI-Rb1, Y79 and HXO-RB44; RPE cell line ARPE-19 |
| Methods | transfection, qPCR, CCK-8 assay, transwell assay, EdU assay, cell cycle assay, TUNEL assay, luciferase reporter assay, Western blot, xenograft |
| Expression pattern | up-regulated |
| Functional description | PVT1 may be a novel biomarker for prognosis and a new target for the treatment of RB. The analysis of the mechanisms of action revealed that the reduction of PVT1 inhibited the expression of notch2 by upregulating miR-488-3p. |
| PubMed ID | 30797143 |
| Year | 2019 |
| Title | Knockdown of lncRNA PVT1 inhibits retinoblastoma progression by sponging miR-488-3p. |
| Drug-related ncRNA | NO |
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